Opportunity Information: Apply for W81XWH 18 BCRP BTA12
The DoD Breast Cancer Research Program (BCRP) Breakthrough Award Levels 1 and 2 (Funding Opportunity Number W81XWH-18-BCRP-BTA12) is a discretionary research funding opportunity administered by the Department of Defense through the U.S. Army Medical Research Acquisition Activity (USAMRAA). Its central purpose is to back breast cancer research that is genuinely poised to change the field, meaning work that can plausibly lead to major advances rather than incremental improvements. The mechanism is offered as grants and cooperative agreements under CFDA 12.420, and it is broadly open to applicants (unrestricted eligibility, subject to any specific eligibility language in the full announcement). The posting was created March 27, 2018, with an original closing date of May 30, 2018, and the program anticipated making around 47 awards.
What sets this award apart is the emphasis on impact. Projects must be framed around the idea of accelerating progress toward ending breast cancer, either in the near term or over a longer horizon, but in a way that clearly goes beyond a minor step forward. The program is looking for research that could produce a new approach that is fundamentally better than current interventions, including those already approved or even those already moving through clinical development. A practical expectation is that applications spell out who ultimately benefits: investigators are expected to identify the breast cancer patient populations or at-risk individuals their work is meant to help, rather than leaving the relevance implicit.
The opportunity is organized around two funding levels that reflect the maturity and scope of the science, not simply the size of the budget. Applicants are responsible for choosing the level that best fits the project they are proposing. Funding Level 1 is intended for innovative, high-risk/high-reward ideas that are still in early development. These projects may be exploratory and are often aimed at opening up entirely new lines of inquiry. The goal at this level is typically proof of concept, and importantly, preliminary data are not required. Funding Level 2 is designed for projects that already have preliminary data in hand and are positioned to make meaningful progress toward clinical translation. In other words, Level 2 supports work that has moved past purely speculative stages and can credibly argue a path toward patient-relevant application, even if it is not yet ready for a clinical trial.
Collaboration is explicitly encouraged through a Partnering PI Option. Under this structure, two investigators can apply together as an Initiating PI and a Partnering PI, with each PI receiving a separate award while contributing to a single, coordinated research effort. The program expects both PIs to play substantial roles in shaping the science and key application components, including the project narrative and the statement of work. The value proposition needs to be clear: applicants should explain what distinct expertise each PI brings and why the project is stronger as a true partnership rather than two parallel projects. New collaborations are welcomed but not mandatory. At the same time, the program discourages using the Partnering PI role repeatedly across multiple submissions unless the applications are clearly focused on different research questions. It also draws a firm line on mentorship pairings: applications that pair a mentor with their current postdoctoral fellow or junior investigator as the two PIs are stated as not meeting the intent of this partnering mechanism.
From a project design standpoint, the program expects PIs to assemble a capable and well-matched research team with the appropriate technical backgrounds and breast cancer-relevant expertise to deliver the work. Studies involving human subjects or human anatomical substances are allowed, which gives applicants room to incorporate patient samples, biospecimens, or other human-derived materials when scientifically justified. However, clinical trials are not permitted under this Levels 1 and 2 announcement. Investigators who want to run a clinical trial are directed instead to the separate FY18 BCRP Breakthrough Award Levels 3 and 4 announcement (W81XWH-18-BCRP-BTA34), which is designed to accommodate that kind of work.
Finally, the program places a clear relevance requirement on proposed research: it must be applicable to active duty Service members, Veterans, military beneficiaries, and/or the American public. Practically, this means applicants should be prepared to connect their scientific goals to real-world breast cancer needs in these populations, aligning the research rationale with broader public health and military community impact rather than presenting the work as purely academic.Apply for W81XWH 18 BCRP BTA12
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Breast Cancer, Breakthrough Award Levels 1 and 2" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Mar 27, 2018.
- Applicants must submit their applications by May 30, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 47 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD Breast Cancer Research Program (BCRP) Breakthrough Award Levels 1 and 2 (W81XWH-18-BCRP-BTA12)
What is this funding opportunity?
The Breast Cancer Research Program (BCRP) Breakthrough Award Levels 1 and 2 is a discretionary research funding opportunity administered by the U.S. Department of Defense (DoD) through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It supports breast cancer research that is positioned to make major advances in the field, not incremental progress.
What is the main goal of the Breakthrough Award Levels 1 and 2?
The central goal is impact: funding projects that can plausibly accelerate progress toward ending breast cancer in a meaningful way. Applications are expected to propose work that could lead to a fundamentally better approach than current interventions, including approaches that are already approved or currently in clinical development.
Who is the funding agency and administrator?
The funding is provided by the Department of Defense, and the opportunity is administered through the U.S. Army Medical Research Acquisition Activity (USAMRAA).
What is the Funding Opportunity Number (FON)?
The Funding Opportunity Number is W81XWH-18-BCRP-BTA12.
What funding mechanisms are used (grant vs cooperative agreement)?
This opportunity is offered as grants and cooperative agreements under CFDA 12.420.
What is CFDA 12.420 in this context?
CFDA 12.420 is the catalog identifier associated with this DoD breast cancer research assistance program. In this announcement, the Breakthrough Award Levels 1 and 2 are offered under that CFDA listing.
Who is eligible to apply?
Eligibility is described as broadly open (unrestricted eligibility), subject to any specific eligibility language included in the full announcement.
How many awards were anticipated?
The program anticipated making around 47 awards.
When was the opportunity posted and what was the original closing date?
The posting was created on March 27, 2018, with an original closing date of May 30, 2018.
What makes this award different from more typical research grants?
The emphasis is on breakthroughs and field-changing impact. Projects should go beyond a minor step forward and instead be framed around accelerating progress toward ending breast cancer, either in the near term or over a longer horizon.
Do applicants need to explain who benefits from the research?
Yes. A practical expectation is that applications clearly identify the breast cancer patient populations or at-risk individuals the research is intended to help, rather than leaving relevance implicit.
What are the two funding levels and how should applicants choose?
The opportunity is organized into Funding Level 1 and Funding Level 2. Applicants are responsible for choosing the level that best fits the maturity and scope of their proposed science (not simply the size of the budget).
What is Funding Level 1 intended to support?
Funding Level 1 supports innovative, high-risk/high-reward ideas that are still early in development. These projects may be exploratory and aimed at opening entirely new lines of inquiry, with proof of concept as a common goal.
Is preliminary data required for Funding Level 1?
No. Preliminary data are not required for Funding Level 1.
What is Funding Level 2 intended to support?
Funding Level 2 supports projects that already have preliminary data and are positioned to make meaningful progress toward clinical translation. These projects should credibly argue a path toward patient-relevant application, even if they are not yet ready for a clinical trial.
Is preliminary data required for Funding Level 2?
Yes. Funding Level 2 is designed for projects that already have preliminary data in hand.
Are clinical trials allowed under Breakthrough Award Levels 1 and 2?
No. Clinical trials are not permitted under this Levels 1 and 2 announcement.
If a project includes a clinical trial, where should it be submitted?
Investigators who want to run a clinical trial are directed to the separate FY18 BCRP Breakthrough Award Levels 3 and 4 announcement: W81XWH-18-BCRP-BTA34.
Are studies with human subjects or human anatomical substances allowed?
Yes. Studies involving human subjects or human anatomical substances are allowed, which can include patient samples, biospecimens, or other human-derived materials when scientifically justified.
What is the Partnering PI Option?
The Partnering PI Option allows two investigators to apply together as an Initiating PI and a Partnering PI. Each PI receives a separate award while contributing to a single, coordinated research effort.
What is expected of the Initiating PI and Partnering PI in a joint application?
The program expects both PIs to play substantial roles in shaping the science and key application components, including the project narrative and the statement of work.
Does the program require that PIs be new collaborators?
No. New collaborations are welcomed but not mandatory.
What should applicants explain when using the Partnering PI Option?
Applicants should explain the distinct expertise each PI brings and why the project is stronger as a true partnership rather than two parallel projects.
Are there limits or cautions about using the Partnering PI Option across multiple submissions?
Yes. The program discourages using the Partnering PI role repeatedly across multiple submissions unless the applications are clearly focused on different research questions.
Can a mentor and their current postdoc or junior investigator apply together as the two PIs?
No. The opportunity states that pairing a mentor with their current postdoctoral fellow or junior investigator as the two PIs does not meet the intent of the partnering mechanism.
What are expectations for the research team?
Applicants are expected to assemble a capable, well-matched team with appropriate technical backgrounds and breast cancer-relevant expertise to carry out the proposed work.
What relevance requirement applies to proposed research?
Proposed research must be applicable to active duty Service members, Veterans, military beneficiaries, and/or the American public.
How should applicants address relevance to military and public populations?
Applicants should connect their scientific goals to real-world breast cancer needs in these populations, aligning the research rationale with broader public health and military community impact rather than presenting the work as purely academic.
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